Gene name:
Smc4 (Capc;Smc4l1) ;
Protein name:
Structural maintenance of chromosomes protein 4 (SMC protein 4;SMC-4) ;
Alternative:
XCAP-C homolog ;Chromosome-associated polypeptide C ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.
Function:
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Location:
Nucleus
Cytoplasm
Chromosome
In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Protein Attributes:
50:
MRRKGTKPST | ACHQEEGPPP | SQDGAHSDEE | MEQPAGEAES | AAPAKPPGEE |
100:
LDNRSLEEIL | NSIPPPPPPA | MASEAGAPRL | MITHIVNQNF | KSYAGEKVLG |
150:
PFHKRFSCII | GPNGSGKSNV | IDSMLFVFGY | RAQKIRSKKL | SVLIHNSDEH |
200:
KDIQSCTVEV | HFQKIIDKEG | DDYEVLPNSN | FYVSRTAYRD | STSVYHISGK |
250:
KKTFKDVGNL | LRSHGIDLDH | NRFLILQGEV | EQIAMMKPKG | QTEHDEGMLE |
300:
YLEDIIGCGR | LNEPIKVLCR | RVEILNEHRG | EKLNRVKMVE | KEKDALEGEK |
350:
NIAIEFLTLE | NEMFKKKNHI | CQYYIYDLQN | RIAEITTQKE | KIHEDTKEIT |
400:
EKSNVLSNEM | KAKNSAVKDV | EKKLNKVTKF | IEQNKEKFTQ | LDLEDVQVRE |
450:
KLKHATSKAK | KLEKQLQKDK | EKVEELKSVP | AKSKTVINET | TTRNNSLEKE |
500:
REKEEKKLKE | VMDSLKQETQ | GLQKEKEIQE | KELMGFNKSV | NEARSKMEVA |
550:
QSELDIYLSR | HNTAVSQLSK | AKEALITASE | TLKERKAAIK | DINTKLPQTQ |
600:
QELKEKEKEL | QKLTQEEINL | KSLVHDLFQK | VEEAKSSLAM | NRSRGKVLDA |
650:
IIQEKKSGRI | PGIYGRLGDL | GAIDEKYDIA | ISSCCHALDY | IVVDSIDTAQ |
700:
ECVNFLKKHN | IGIATFIGLD | KMTVWAKKMS | KIQTPENTPR | LFDLVKVKNE |
750:
EIRQAFYFAL | RDTLVANNLD | QATRVAYQRD | RRWRVVTLQG | QIIEQSGTMS |
800:
GGGSKVMRGR | MGSSVIDEIS | VEEVNKMESQ | LERHSKQAMQ | IQEQKVQHEE |
850:
AVVKLRHSER | DMRNTLEKFA | ASIQGLSEQE | EYLCVQIKEL | EANVLTTAPD |
900:
RKQQKLLEEN | VSVFKKEYDA | VAEKAGKVEA | EIKRLHNTII | DINNRKLKAQ |
950:
QNKLDTINKQ | LDECASAITK | AQVAIKTADR | NLKKAQDSVC | RTEKEIKDTE |
1000:
KEINDLKTEL | KNIEDKAEEV | INNTKTAETS | LPEIQKEHRN | LLQELKVIQE |
1050:
NEHALQKDAL | SIKLKLEQID | GHISEHNSKI | KYWQKEISKI | KLHPVEDNPV |
1100:
ETVAVLSQEE | LEAIKNPESI | TNEIALLEAQ | CREMKPNLGA | IAEYKKKEDL |
1150:
YLQRVAELDK | ITSERDNFRQ | AYEDLRKQRL | NEFMAGFYVI | TNKLKENYQM |
1200:
LTLGGDAELE | LVDSLDPFSE | GIMFSVRPPK | KSWKKIFNLS | GGEKTLSSLA |
1250:
LVFALHHYKP | TPLYFMDEID | AALDFKNVSI | VAFYIYEQTK | NAQFIIISLR |
1286:
NNMFEISDRL | IGIYKTYNST | KSVAVNPKQI | ASKGLC
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse SMC protein 4
ELISA Kit for Mouse SMC protein 4
CLIA Kit for Mouse SMC protein 4
CLIA Kit for Mouse SMC protein 4
Polyclonal Antibody for Mouse SMC protein 4
Polyclonal Antibody for Mouse SMC protein 4
Monoclonal Antibody for Mouse SMC protein 4
Monoclonal Antibody for Mouse SMC protein 4
Protein for Mouse SMC protein 4
Protein for Mouse SMC protein 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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C57BL/6J .
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-602
strain :
NOD .
tissue :
Thymus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-379;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .